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That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin. ↗
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In fact, from then on scholars engaged in a kind of game of comparing different Indo-European languages with one another, and eventually they could not fail to wonder what exactly these connections showed, and how they should be interpreted in concrete terms. ↗
