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Read through the most famous quotes by topic #hang
Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so. ↗
#chance #darwinism #evolution #macro-evolution #macroevolution
Be fanatically positive and militantly optimistic. If something is not to your liking, change your liking. ↗
We have no idea, now, of who or what the inhabitants of our future might be. In that sense, we have no future. Not in the sense that our grandparents had a future, or thought they did. Fully imagined cultural futures were the luxury of another day, one in which 'now' was of some greater duration. For us, of course, things can change so abruptly, so violently, so profoundly, that futures like our grandparents' have insufficient 'now' to stand on. We have no future because our present is too volatile. ... We have only risk management. The spinning of the given moment's scenarios. Pattern recognition ↗
I read the first chapter of A Brief History of Time when Dad was still alive, and I got incredibly heavy boots about how relatively insignificant life is, and how compared to the universe and compared to time, it didn't even matter if I existed at all. When Dad was tucking me in that night and we were talking about the book, I asked if he could think of a solution to that problem. "Which problem?" "The problem of how relatively insignificant we are." He said, "Well, what would happen if a plane dropped you in the middle of the Sahara Desert and you picked up a single grain of sand with tweezers and moved it one millimeter?" I said, "I'd probably die of dehydration." He said, "I just mean right then, when you moved that single grain of sand. What would that mean?" I said, "I dunno, what?" He said, "Think about it." I thought about it. "I guess I would have moved one grain of sand." "Which would mean?" "Which would mean I moved a grain of sand?" "Which would mean you changed the Sahara." "So?" "So? So the Sahara is a vast desert. And it has existed for millions of years. And you changed it!" "That's true!" I said, sitting up. "I changed the Sahara!" "Which means?" he said. "What? Tell me." "Well I'm not talking about painting the Mona Lisa or curing cancer. I'm just talking about moving that one grain of sand one millimeter." "Yeah? If you hadn't done it, human history would have been one way..." "Uh-huh?" "But you did do it, so...?" I stood on the bed, pointing one of my fingers at the fake stars, and screamed: "I changed the course of human history!" "That's right." "I changed the universe!" "You did." "I'm God!" "You're an atheist." "I don't exist!" I fell back onto the bed, into his arms, and we cracked up together. ↗
Sure," said Adrian. "I bet going in there and kicking down the door will change their minds. Take Rose with you, and you guys'll make a really good impression. ↗
I should have known what you would do,” Jem said in a low voice. “I always know what you will do. I should have known you would put your hands into the fire.” “And I should have known you would throw that packet away,” said Will, without rancor. “It was—it was a madly noble thing to do. I understand why you did it.” “I was thinking of Tessa.” Jem drew his knees up and rested his chin on them, then laughed softly. “Madly noble. Isn’t that meant to be your area of expertise? Suddenly I am the one who does ridiculous things and you tell me to stop?” “God,” said Will. “When did we change places?” The firelight played over Jem’s face and hair as he shook his head. “It is a very strange thing, to be in love,” he said. “It changes you.” Will looked down at Jem, and what he felt, more than jealousy, more than anything else, was a wistful desire to commiserate with his best friend, to speak of the feelings he held in his heart. For were they not the same feelings? Did they not love the same way, the same person? But, “I wish you wouldn’t risk yourself,” was all he said. Jem stood up. “I have always wished that about you.” Will raised his eyes, so drowsy with sleep and the tiredness that came with healing runes that he could see Jem only as a haloed figure of light. “Are you going?” “Yes, to sleep.” Jem touched his fingers lightly to Will’s healing hands. “Let yourself rest, Will. ↗
There has never been a just [war], never an honorable one--on the part of the instigator of the war. I can see a million years ahead, and this rule will never change in so many as half a dozen instances. The loud little handful--as usual--will shout for the war. The pulpit will--warily and cautiously--object--at first; the great, big, dull bulk of the nation will rub its sleepy eyes and try to make out why there should be a war, and will say, earnestly and indignantly, 'It is unjust and dishonorable, and there is no necessity for it.' Then the handful will shout louder. A few fair men on the other side will argue and reason against the war with speech and pen, and at first will have a hearing and be applauded; but it will not last long; those others will outshout them, and presently the anti-war audiences will thin out and lose popularity. Before long you will see this curious thing: the speakers stoned from the platform, and free speech strangled by hordes of furious men who in their secret hearts are still at one with those stoned speakers--as earlier--but do not dare say so. And now the whole nation--pulpit and all--will take up the war-cry, and shout itself hoarse, and mob any honest man who ventures to open his mouth; and presently such mouths will cease to open. Next the statesmen will invent cheap lies, putting the blame upon the nation that is attacked, and every man will be glad of those conscience-soothing falsities, and will diligently study them, and refuse to examine any refutations of them; and thus he will by and by convince himself the war is just, and will thank God for the better sleep he enjoys after this process of grotesque self-deception. ↗
We look for medicine to be an orderly field of knowledge and procedure. But it is not. It is an imperfect science, an enterprise of constantly changing knowledge, uncertain information, fallible individuals, and at the same time lives on the line. There is science in what we do, yes, but also habit, intuition, and sometimes plain old guessing. The gap between what we know and what we aim for persists. And this gap complicates everything we do. ↗
