#tide

According to an article in the Washington Post: The Food and Drug Administration has repeatedly urged antidepressant manufacturers not to disclose to physicians and the public that some clinical trials of the medications in children found that drugs were no better than sugar pills, according to documents and testimony released at a congressional hearing yesterday. Regulators supressed the negative information on the grounds that it might scare families and physicians away from the drugs, according to testimony by drug company executives. For at least three medications, they said, the FDA blocked the companies' plans to reveal the negative studies in drug labels. ↗

— Irving Kirsch

#negative #studies #family

The sea is calm tonight. The tide is full, the moon lies fair Upon the straits;- on the French coast the light Gleams and is gone; the cliffs of England stand, glimmering and vast, out in the tranquil bay. ↗

— Matthew Arnold

#britain #calm #cliffs #coast #home

Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances. The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence. ↗

— Irving Kirsch

#depression #communication

The emotions attached to them were like sand castles in the tide, slowly washing out to sea. ↗

— Nicholas Sparks

#feeling #life #sand-castle #tide #life

It's so critical for people frustrated with the economy, with changing tides in government, who aren't able to hear their voices, questions or their ills being talked about, to have a place for discussing what others won't. ↗

— George Noory

#about #being #changing #critical #discussing

In a still hot morning, the tide went out and didn't come back in. This was not a spectacular event. The sea did not roll up like a scroll, like the sky in Revelations. It quietly withdrew. ↗

— Ruth Park

#come #did #event #hot #like

Events are moving so fast and what in one moment seems impossible, the next is happening. I'm sure historians will, in time, provide theories and analysis, but for now I think most of us simply want the tide stemmed. ↗

— Lucy Powell

#events #fast #happening #historians #i

There is a tide in the affairs of men, Which taken at the flood, leads on to fortune. Omitted, all the voyage of their life is bound in shallows and in miseries. On such a full sea are we now afloat. And we must take the current when it serves, or lose our ventures. ↗

— William Shakespeare

#afloat #bound #current #flood #fortune

Hoist up sail while gale doth last, Tide and wind stay no man's pleasure. ↗

— Robert Southwell

#gale #hoist #last #man #pleasure

You make something, and you really have fun with it, and you try to put emotion in it, and at the end of the day, you have no idea how the tide is going to fall. You don't know if everyone's going to like it, if everyone's going to hate it, if it's going to be like you're a media darling, or all of a sudden you're a sellout. You have no idea. ↗

— Regina Spektor

#day #emotion #end #end of the day #everyone