Let me remind you of the old maxim: people under suspicion are better moving than at rest, since at rest they may be sitting in the balance without knowing it, being weighed together with their sins. ↗
The individual organs follow the same pattern as the whole organism, i.e. they have their period of growth, of stationary, maximum activity and then of aging decline. ↗
In the 1980s, there were occasions when it made sense to say, 'it is too difficult to maximize the likelihood function, and besides if we do, it will blow our model out of the water.' ↗
The first and most optimistic response was complete rational expectations econometrics. A rational expectations equilibrium is a likelihood function. Maximize it. ↗