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(1702–1778) Massachusetts lawyer and public official
James Otis Jr. (1725–1783) American revolutionary politician from Massachusetts
James Otis (politician) (1826–1875) mayor of San Francisco California
James Otis (actor) American film and television actor
James Otis Kaler (1848–1912) (pen name: James Otis) American journalist and author of children’s literature
Jim Otis American football player.