Mirth, and even cheerfulness, when employed as remedies in low spirits, are like hot water to a frozen limb.

As an Enlightenment intellectual he was committed to organizing all medical knowledge around explanatory theories rather than rely on empirical methods. December 24 1745] – April 19 1813) was a Founding Father of the United States. He signed the Declaration of Independence and was a leader in Pennsylvania's ratification the Constitution in 1788.