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He also starred in The Outer Limits episode "Glitch" and in the series Crossing Jordan. The couple had two children before separating in 1974. Klugman's last on-screen role was in the 2010 horror film Camera Obscura.
Klugman married actress Brett Somers in 1953. The cancer returned in 1989. From 1976 to 1983 he starred in the title role in Quincy M.