I wanna do movies that in ten years time people will respect me for, as an actor. So if I do take two years off or three years off, the next movie I have that comes out you want people to go 'ooh, that's Frankie Muniz's new movie, it's gonna be a good movie cause he's in it.'

That same year he played the voice of Domino in the 2000 video game 102 Dalmatians: Puppies to the Rescue. That same year he appeared in the series premiere of Ashton Kutcher's MTV practical joke series Punk'd. Muniz entered fourteen races during the 2006 Formula BMW USA series and failed to finish in a point-scoring position.

" In 2008 he put his acting career on hold to pursue an open wheel racing career. He is known primarily as the star of the FOX television family sitcom Malcolm in the Middle which has earned him an Emmy-Award Nomination and two Golden Globe Award Nominations.