The key to sitcom success is miserable people. If you see a happy couple, it's just gone, like when Sam and Diane got together on Cheers.

Sunshine based on Perry's original idea was bought by ABC. He also appeared in David Mamet's Sexual Perversity in Chicago in London. In 2006-2007 Perry appeared in Aaron Sorkin's drama Studio 60 on the Sunset Strip.

He is well known for his Emmy-nominated role as Chandler Bing on the popular long-running NBC television sitcom Friends. Sunshine which ran from February to April 2011. Perry also starred in the short-lived series Studio 60 on the Sunset Strip and has appeared in a number of films including Fools Rush In (1997) The Whole Nine Yards (2000) and 17 Again (2009).