But Nature cast me for the part she found me best fitted for, and I have had to play it, and must play it till the curtain falls.

Influence on acting
Edwin's acting style was distinctly different from that of his father. A second play by the same name The Brothers Booth which focuses on "the world of the 1860s theatre and its leading family" was written by MarEdwin Boothll Bradley and staged in New York at the Perry Street Theatre in 2004. For comparison the family hoped to obtain DNA samples from artifacts belonging to John Wilkes such as vertebrae stored at the National Museum of Health and Medicine in Maryland.

In 1869 he founded Booth's Theatre in New York a spectacular theatre that was quite modern for its time. Some theatrical historians consider him the greatest American actor and the greatest Hamlet of the 19th century.