Heath, I believed in him when I first met him, and helped and supported him. He went on to obvious success in the States and then I had him support me. It can be a lonely, horrible, hard place. It's great just to have someone to call to say 'I know, man, I was there'

In 2010 it was announced Henderson had been cast in Grey's Anatomy creator Shonda Rhime's new television series Off the Map wherein doctors travel to the end of the world to rediscover why they had initially wanted to become doctors. In 2006 Henderson won rave reviews in London's West End in a theatre production of Fool for Love with Juliette Lewis. In 2005 he starred opposite Indian actress Aishwarya Rai in the romantic film Bride & Prejudice and in the award-winning Little Fish starring Cate Blanchett.