The offer of certainty, the offer of complete security, the offer of an impermeable faith that can’t give way, is an offer of something not worth having. I want to live my life taking the risk all the time that I don’t know anything like enough yet; that I haven’t understood enough; that I can’t know enough; that I’m always hungrily operating on the margins of a potentially great harvest of future knowledge and wisdom. I wouldn’t have it any other way.

In November 2010 Hitchens cancelled a scheduled appearance in New York where he was to debate writers David Hazony and Stephen Prothero on the subject of the Ten Commandments. He also criticised Bush's support of intelligent design and capital punishment. He will tell it really well.

His anti-religion polemic God Is Not Great sold over 500000 copies. Hitchens died on 15 December 2011 from complications arising from oesophageal cancer a disease that he acknowledged was likely due to his lifelong predilection for heavy smoking and drinking.