Francis Crick

We've discovered the secret of life. ↗

— Francis Crick

#discovered the secret #life #secret

A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement. ↗

— Francis Crick

#agreement #amino #amino acid #between #changes

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here. ↗

— Francis Crick

#amino #amino acid #detailed #discussed #final

Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap. ↗

— Francis Crick

#base #certain #codons #fairly #find

For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few. ↗

— Francis Crick

#class #extra #few #genetic #having

How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons. ↗

— Francis Crick

#backbone #base #bases #codons #divided

If poly A is added to poly U, to form a double or triple helix, the combination is inactive. ↗

— Francis Crick

#combination #double #form #triple

If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it. ↗

— Francis Crick

#attempt #bad #both #code #consider

It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code. ↗

— Francis Crick

#code #direct #earlier #evidence #genetic

It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. ↗

— Francis Crick

#amino #amino acid #any #bases #certain