It's hard for women to talk about these things, and for the doctors to really talk about it too, and to even have the knowledge of what's going on. That's why I'm doing this and urging women to speak out and talk to their doctors frankly.

Robert De Niro asked her out during the filming of Taxi Driver (1976). She did not like working with Charles Grodin on The Heartbreak Kid (1972) and that it took her several years to like him enough to have a one-night stand with him. She later canceled the date and Nicholson would not speak to her again except to say "hi" at a party many years later.

Her better known roles include starring as Jacy in The Last Picture Show (1971) as Betsy in Taxi Driver (1976) as Maddie Hayes in Moonlighting (1985–1989) as Cybill Sheridan in Cybill (1995–1998) as Phyllis Kroll in The L Word (2007–2009) and as Madeleine Spencer in Psych (2008–2010).