I don't remember a time when I wasn't acting. I have taken time off to figure out if it's what I really want to do, and it is. The only other job I'd want is to be a psychologist, as I spend most of my time analyzing people and emotions.

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Wood provided the voice of an alien named Mala a mechanically inclined free-thinker in Battle for Terra a 2008 computer-animated science fiction film about a peaceful alien planet that faces destruction from colonization by the displaced remainder of the human race. Her paternal aunt Carol Winstead Wood was a Hollywood production designer. Of her performance one critic wrote "Once her character stops stonewalling her father and hears him out Wood provides a fine foil for Rourke in their turbulent scenes together.

She made her début as a leading film actress in Little Secrets (2002) and became well known after her transition to a more adult-oriented Golden Globe-nominated role in the teen drama film Thirteen (2003). " Her personal life particularly her relationship with Marilyn Manson to whom Evan Rachel Wood was engaged until August 2010 has attracted press attention.