In the beginning, when I first found out I had a disease that was incurable, emotionally I had to get used to the idea of being sick before I could think about making any other major decisions in my life.

Personal life
Duffy was leading a relatively carefree youth in the heyday of her modeling career when in 1995 Karen Duffy was diagnosed with the relatively rare disease sarcoidosis. In 2006 Duffy hosted House of Tiny Terrors on TLC. Karen Duffy.