As a teenager, even as a younger girl, I had some depression but no one really noticed that it was depression nor did I know in those days that that's what it was but I did feel different from other people.

Hamilton next starred opposite Ron Perlman in the TV series Beauty and the Beast. She studied for two years at Washington College in Chestertown Maryland before moving on to acting studies in New York City. Destiny and in 1991 with Terminator 2: Judgment Day the sequel to The Terminator.

Hamilton had a recurring role as Mary Elizabeth Bartowski on NBC's Chuck.