I'm getting a lot of roles as women who are very powerful. I think that's a reflection of me as a person.

She also appeared in the Seinfeld episode "The Muffin Tops" playing Jerry's girlfriend who likes anything hairless. Clarke is best known for playing Faith Taylor on the daytime drama Days of our Lives the manipulative and cunning Julie Cooper-Nichol on The O. As of 2010 Melinda Clarke portrays Amanda on the action-thriller television series Nikita.

Clarke is best known for playing Faith Taylor on the daytime drama Days of our Lives the manipulative and cunning Julie Cooper-Nichol on The O. and the professional dominatrix Lady Heather on CSI.