It's not even about black and white anymore, because so many people are from mixed backgrounds and mixed ethnicities, and it's just a great time to be able to pull all that together.

Lopez was a cast member and commentator for HBO’s hit sports show Inside the NFL for the 2003–2004 football season. Kirstie responded on Twitter "Don't worry about George's comments…just remember what happens to the big bad drunk woolf…falls in a boiling pot of vodka. He also claimed he had a physical altercation with Mencía over the alleged appropriation.

His stand-up comedy examines race and ethnic relations including Mexican American culture. He is mostly known for starring in his self-produced ABC sitcom George Lopez. He was the host of the late-night talk show Lopez Tonight on TBS until its cancellation on August 12 2011.